Epilepsia partialis continua after an anterior circulation ischaemic stroke

• Published in: European journal of neurology Vol. 24; no. 7; pp. 929 - 934
• Main Authors: Bentes, C., Franco, A. C., Peralta, A. R., Viana, P., Martins, H., Morgado, C., Casimiro, C., Fonseca, C., Geraldes, R., Canhão, P., Pinho e Melo, T., Paiva, T., Ferro, J. M.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.07.2017
• Subjects: Aged; Aged, 80 and over; Attention; Brain Ischemia - complications; Brain Ischemia - diagnostic imaging; Brain Ischemia - epidemiology; Cerebral Arteries - diagnostic imaging; cerebral infarction; Cerebrovascular Circulation; Cerebrovascular diseases; Circulation; Consciousness; Convulsions & seizures; cortical myoclonus; Criteria; Diagnosis; Diagnostic systems; Disorders; EEG; Electroencephalography; Electromyography; epilepsia partialis continua; Epilepsia Partialis Continua - diagnostic imaging; Epilepsia Partialis Continua - epidemiology; Epilepsia Partialis Continua - etiology; Epilepsy; Evaluation; Female; Fragmentation; Fragments; Health care; Humans; Imaging; Incidence; jerk‐locked back averaging analysis; Low frequencies; Male; Middle Aged; Myoclonus; Neuroimaging; Neurologic Examination; Patients; Prognosis; Prospective Studies; Seizing; Seizures; status epilepticus; Stroke; Stroke - complications; Stroke - diagnostic imaging; Stroke - epidemiology; status epilepticus; cerebral infarction; epilepsia partialis continua; jerk-locked back averaging analysis; stroke; cortical myoclonus
• ISSN: 1351-5101; 1468-1331
• DOI: 10.1111/ene.13310

Background and purpose Although cerebrovascular disorders are the main cause of epilepsia partialis continua (EPC) in adulthood, the frequency of EPC after stroke is unknown. The aim was to prospectively ascertain its frequency 1 year after an ischaemic stroke. Methods This was a prospective study of consecutive acute anterior circulation ischaemic stroke patients, previously independent, with an admission National Institutes of Health Stroke Scale score ≥4, an acute ischaemic lesion on imaging and no previous epileptic seizures. During admission patients received standardized diagnostic and medical care and were submitted to a neurophysiological evaluation protocol. One year after stroke, patients were re‐evaluated by an epilepsy expert neurologist and performed a video‐electroencephalogram with electromyography co‐registration whenever myoclonus was observed during neurological examination for jerk‐locked back averaging analysis (JLBA). EPC was defined as continuously repeated fragments of epileptic seizures, with preserved consciousness, lasting at least 1 h, and representing locally restricted epileptic activity. Results In all, 151 acute anterior circulation stroke patients were consecutively included and prospectively evaluated, but 23 died in the first year. One year after stroke, from 127 patients alive, 117 (92.1%) underwent clinical and neurophysiological evaluation. In two (1.7%) patients, EPC diagnosis was made both by clinical and electroencephalographic criteria, namely JLBA. Both patients had a history of remote symptomatic seizures and one of them acute symptomatic seizures and non‐convulsive status epilepticus criteria during the first 7 days after stroke. Conclusions Despite its low frequency, the high stroke incidence makes post‐stroke EPC relevant. This study draws attention to this recognizable condition with therapeutic and eventually prognostic implications.