Localization of area prostriata and its connections with primary visual cortex in rodent

Area prostriata (Pro) has been found to play important roles in the rapid processing of moving stimuli in the far peripheral visual field. However, the specific neural substrates responsible for these functions remain unknown. In this study, we first examined the location, extent, and topography of...

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Published inJournal of comparative neurology (1911) Vol. 528; no. 3; pp. 389 - 406
Main Authors Lu, Weiye, Chen, Shengqiang, Chen, Xiexian, Hu, Jinmeng, Xuan, Aiguo, Ding, Song‐Lin
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 15.02.2020
Wiley Subscription Services, Inc
Subjects
Adcyap1
Brain architecture
C1ql2
calbindin‐D28k
connectivity
cytoarchitecture
Localization
retrosplenial cortex
RRID: AB_10841576
RRID: AB_331277
Tracers
Visual cortex
Visual field
Visual stimuli
C1ql2
connectivity
RRID: AB_10841576
visual cortex
RRID: AB_331277
Adcyap1
calbindin-D28k
cytoarchitecture
retrosplenial cortex
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Summary:Area prostriata (Pro) has been found to play important roles in the rapid processing of moving stimuli in the far peripheral visual field. However, the specific neural substrates responsible for these functions remain unknown. In this study, we first examined the location, extent, and topography of the rodent equivalent of the primate Pro based on cytoarchitecture and molecular markers. We then identified its intimate connections with the primary visual cortex (V1) using retrograde and anterograde tracers. Our main finding is that medial V1, which receives peripheral visual information, has strong reciprocal connections with the Pro in both rat and mouse while lateral V1 has significantly fewer such connections. The direct V1 inputs to the Pro provide at least one of the shortest pathways for visual information to reach the Pro, and may be crucial to the fast processing of unexpected stimuli in the peripheral visual field. Rodent prostriata (Pro) is a distinct area from adjoining regions. The Pro displays strong expression of some genes such as Adcyap1, Htr1a, Calb1, and C1ql2 and unique connectivity. The Pro has strong and weak connections with medial and lateral primary visual cortex (V1), respectively.
Bibliography:Funding information
National Natural Science Foundation of China, Grant/Award Number: 31771327
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ISSN:0021-9967
1096-9861
1096-9861
DOI:10.1002/cne.24760