Chinese visceral adiposity index: A reliable indicator of visceral fat function associated with risk of type 2 diabetes

• Published in: Diabetes/metabolism research and reviews Vol. 37; no. 2; pp. e3370 - n/a
• Main Authors: Han, Minghui, Qin, Pei, Li, Quanman, Qie, Ranran, Liu, Leilei, Zhao, Yang, Liu, Dechen, Zhang, Dongdong, Guo, Chunmei, Zhou, Qionggui, Tian, Gang, Huang, Shengbing, Wu, Xiaoyan, Li, Yang, Yang, Xingjin, Feng, Yifei, Liu, Yu, Li, Honghui, Sun, Xizhuo, Chen, Qing, Wang, Tieqiang, Chen, Xiaoliang, Hu, Dongsheng, Zhang, Ming
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Inc 01.02.2021; Wiley Subscription Services, Inc
• Subjects: Adipose tissue; Body mass index; China - epidemiology; Chinese visceral adiposity index; Cohort analysis; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - epidemiology; Humans; Intra-Abdominal Fat - physiology; Obesity; Obesity, Abdominal - epidemiology; Population studies; prospective cohort study; Prospective Studies; receiver operating characteristic; Risk Factors; Sensitivity analysis; type 2 diabetes mellitus; China; type 2 diabetes mellitus; prospective cohort study; receiver operating characteristic; Chinese visceral adiposity index
• ISSN: 1520-7552; 1520-7560
• DOI: 10.1002/dmrr.3370

Background The evidence of the association between Chinese visceral adiposity index (CVAI) and risk of type 2 diabetes mellitus (T2DM) is limited. We explored the association of CVAI with T2DM and directly compared with the predictive power of CVAI with other visceral obesity indices (visceral adiposity index, waist to height ratio, waist circumference and body mass index) based on a large prospective study. Methods We conducted a population‐based study of 12 237 Chinese participants. Cox proportional‐hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between CVAI and T2DM. Results During follow‐up (median: 6.01 years), the incidence of T2DM was 3.29, 7.34, 12.37 and 23.72 per 1000 person‐years for quartiles 1, 2, 3 and 4 of CVAI, respectively. The risk of T2DM was increased with quartiles 2, 3 and 4 vs quartile 1 of CVAI (HR 2.12 [95% CI 1.50‐3.00], 2.94 [2.10‐4.13] and 5.01 [3.57‐7.04], Ptrend < 0.001). Per‐SD increase in CVAI was associated with a 72% increased risk of T2DM (HR 1.72 [95% CI 1.56‐1.88]). Sensitivity analyses did not alter the association. The area under receiver operating characteristic curve was significantly higher for CVAI than other visceral obesity indices (all P <.001). Similar results were observed in stratified analyses by sex. Conclusions Our findings show a positive association between CVAI and risk of T2DM. CVAI has the best performance in predicting incident T2DM, so the index might be a reliable and applicable indicator identifying people at high risk of T2DM.