Late locoregional complications associated with adjuvant radiotherapy in the treatment of breast cancer: Systematic review and meta‐analysis

This systematic review with meta‐analysis addressed late locoregional complications associated with adjuvant radiotherapy (RT) in breast cancer. Among 2120 titles, ten comparative studies in patients undergoing surgery vs surgery and radiotherapy reporting complications were evaluated. RT was associ...

Full description

Saved in:
Bibliographic Details
Published inJournal of surgical oncology Vol. 121; no. 5; pp. 766 - 776
Main Authors Kanda, Márcia Helena, Costa Vieira, René Aloisio, Lima, João Paulo S. N., Paiva, Carlos Eduardo, Araujo, Raphael Leonardo Cunha
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.04.2020
Subjects
Breast cancer
Breast Neoplasms - therapy
complications
Contracture - etiology
Female
Humans
Lymphedema
Lymphedema - etiology
Mastectomy
Meta-analysis
Radiation therapy
radiotherapy
Radiotherapy, Adjuvant - adverse effects
Side effects
Systematic review
radiotherapy
breast cancer
side effects
complications
lymphedema
Online AccessGet full text

Cover

More Information
Summary:This systematic review with meta‐analysis addressed late locoregional complications associated with adjuvant radiotherapy (RT) in breast cancer. Among 2120 titles, ten comparative studies in patients undergoing surgery vs surgery and radiotherapy reporting complications were evaluated. RT was associated with an increased risk of capsular contracture and decreased the mobility of the upper limb. A borderline association of lymphedema risk using RT was noted in the random‐effects model but was significant in the fixed‐effects model.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Undefined-3
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.25820