Longitudinal proton spectroscopy study of the prefrontal cortex in youth at risk for bipolar disorder before and after their first mood episode

• Published in: Bipolar disorders Vol. 21; no. 4; pp. 330 - 341
• Main Authors: Nery, Fabiano G., Weber, Wade A., Blom, Thomas J., Welge, Jeffrey, Patino, Luis R., Strawn, Jeffrey R., Chu, Wen‐Jang, Adler, Caleb M., Komoroski, Richard A., Strakowski, Stephen M., DelBello, Melissa P.
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.06.2019
• Subjects: Adolescent; Adolescents; Adult; Affective Symptoms - diagnosis; Affective Symptoms - metabolism; at‐risk; Bipolar disorder; Bipolar Disorder - diagnosis; Bipolar Disorder - metabolism; Child; Child of Impaired Parents - psychology; Choline; Cortex (cingulate); Creatine; Creatine - analysis; Creatine - metabolism; Female; Gyrus Cinguli - metabolism; Humans; Inositol; Longitudinal Studies; Magnetic resonance spectroscopy; Male; Metabolites; Mood; Phosphocreatine; Phosphocreatine - analysis; phosphocreatine and creatine; Prefrontal cortex; Prefrontal Cortex - metabolism; Proton Magnetic Resonance Spectroscopy - methods; Psychosis; Risk Assessment - methods; Spectrum analysis; magnetic resonance spectroscopy; bipolar disorder; at-risk; phosphocreatine and creatine
• ISSN: 1398-5647; 1399-5618
• DOI: 10.1111/bdi.12770

Objectives To investigate neurochemical abnormalities in the left and right ventrolateral prefrontal cortex (VLPFC) and anterior cingulate cortex (ACC) of youth at risk for bipolar disorder using proton magnetic resonance spectroscopy before and after their first mood episode. Methods Children and adolescents offspring of parents with bipolar I disorder (at‐risk group, n = 117) and matched healthy controls (HC group, n = 61) were recruited at the University of Cincinnati. At‐risk subjects had no lifetime major mood and psychotic disorders at baseline, and were followed up every 4 months to monitor for development of a major depressive, manic, hypomanic, or mixed mood episode. Levels of N‐acetyl‐aspartate (NAA), phosphocreatine plus creatine (PCr + Cr), choline‐containing compounds, myo‐inositol, and glutamate were determined using LCModel and corrected for partial volume effects. Results There were no baseline differences in metabolite levels for any of the brain regions between at‐risk and HC youth. Nineteen at‐risk subjects developed a first mood episode during follow‐up. Survival analyses showed that baseline PCr + Cr levels in the left VLPFC significantly predicted a mood episode during follow‐up in the at‐risk group (HR: 0.47, 95% CI: 0.27‐0.82, P = 0.008). There were no longitudinal changes in metabolites levels in the VLPFC and ACC before and after a mood episode in at‐risk subjects. Conclusions We found no evidence for abnormal proton spectroscopy metabolite levels in the VLPFC and ACC of at‐risk youth, prior and after the development of their first mood episode. Preliminary findings of association between baseline PCr + Cr levels in the left VLPFC and risk to develop a mood episode warrant further investigation.