The association of air pollutants and allergic and nonallergic rhinitis in chronic rhinosinusitis

• Published in: International forum of allergy & rhinology Vol. 8; no. 3; pp. 369 - 376
• Main Authors: Mady, Leila J., Schwarzbach, Hannah L., Moore, John A., Boudreau, Robert M., Kaffenberger, Thomas M., Willson, Thomas J., Lee, Stella E.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2018
• Subjects: Absorbance; Adult; air pollutants; Air Pollutants - adverse effects; Air pollution; Allergens; Allergens - immunology; Allergic diseases; Allergic rhinitis; Asthma; Black carbon; Chronic Disease; Cities - epidemiology; environmental exposure; Environmental Exposure - adverse effects; Female; Humans; Hypersensitivity; Male; Middle Aged; nasal polyps; Particulate matter; Particulate Matter - adverse effects; Pennsylvania - epidemiology; Pollutants; Polyps; quality of life; Respiratory tract diseases; Respiratory Tract Diseases - diagnosis; Respiratory Tract Diseases - epidemiology; Rhinitis; Rhinosinusitis; risk factors; Sinusitis; Skin Tests; Cities; Pennsylvania; particulate matter; risk factors; environmental exposure; nasal polyps; sinusitis; asthma; rhinitis; quality of life; air pollutants; allergens
• ISSN: 2042-6976; 2042-6984
• DOI: 10.1002/alr.22060

Background There has been little investigation regarding air quality and rhinitis in the pathophysiology of upper airway disease. In this study, we assessed the impact of inhalant pollutants (particulate matter 2.5 [PM2.5] and black carbon [BC]) on allergic rhinitis and chronic rhinosinusitis (CRS) disease severity. Methods CRS patients with nasal polyps (CRSwNP) and without polyps (CRSsNP) were identified. Spatial modeling from pollutant monitoring sites was used to estimate exposures for patients meeting the inclusion criteria (total, n = 125; CRSsNP, n = 67; CRSsNP, n = 58). Skin‐prick, intradermal dilutional, and in‐vitro testing methods were utilized to determine aeroallergen sensitization. Disease severity indicators were measured by modified Lund‐Mackay score (LMS), the 22‐item Sino‐Nasal Outcome Test (SNOT‐22), systemic steroid therapy, and number of functional endoscopic sinus surgeries (FESS). Results Thirty‐six percent (n = 45) of patients who described rhinitis symptoms demonstrated no reactivity to aeroallergen testing. Sixty‐four percent (n = 80) tested positive for at least 1 allergen, with no differences found between CRSsNP and CRSwNP (62.1% vs 67.2%). There were significant differences in air pollutants between patients testing negative and positive for allergies (nonallergic vs allergic: PM2.5, 11.32 vs 11.07 μg/m3, p = 0.030; BC, 0.81 vs 0.76 absorbance, p =0.044). Nonallergic CRSwNP demonstrated higher PM2.5 compared with allergic counterparts (11.48 vs 11.09 μg/m3, p = 0.032). A similar pattern was observed with BC (0.82 vs 0.75 absorbance, p = 0.017). In CRSsNP, BC correlated significantly with SNOT‐22 (r = 0.55, p = 0.042). Conclusion Our results suggest that small inhalant pollutants may contribute to nonallergic symptomatology in patients with and without nasal polyps. Regardless of allergy status, BC may play a role in CRS symptom severity.