Medical and aesthetic improvement of photodamaged skin by the combination of intense pulsed light and photodynamic therapy with 10% aminolevulinic acid hydrochloride gel

Objective To evaluate the efficacy and safety of photodynamic therapy (PDT) with the novel 10% aminolevulinic acid (ALA) hydrochloride gel (10% ALA gel) and BF‐RhodoLED® light (635 nm; 37 J/cm2) in combination with intense pulsed light (IPL) to augment the medical and aesthetic improvement of photod...

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Bibliographic Details
Published inLasers in surgery and medicine Vol. 54; no. 1; pp. 62 - 65
Main Authors Abrouk, Michael, Dong, Joanna, Waibel, Jill S.
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.01.2022
Subjects
Ameluz
Aminolevulinic acid
Aminolevulinic Acid - therapeutic use
BF‐RhodoLED
Chest
décolletéIP
Esthetics
Female
Humans
IPL
Light effects
otodamageph
otodynamic therapyre
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - therapeutic use
Pilot Projects
Prospective Studies
rejuvenation
Tph
Treatment Outcome
Ameluz
chest
IPL
otodamageph
aminolevulinic acid
BF-RhodoLED
décolletéIP
otodynamic therapyre
rejuvenation
Tph
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Summary:Objective To evaluate the efficacy and safety of photodynamic therapy (PDT) with the novel 10% aminolevulinic acid (ALA) hydrochloride gel (10% ALA gel) and BF‐RhodoLED® light (635 nm; 37 J/cm2) in combination with intense pulsed light (IPL) to augment the medical and aesthetic improvement of photodamaged skin of the décolleté. Methods This was a single‐site prospective, randomized, intraindividual split chest pilot study with 20 female subjects with moderate to severe photodamage of the décolleté. Subjects were randomized to ALA‐PDT + IPL to one split‐side of the chest and ALA‐PDT only to the contralateral side. Three blinded raters assessed aesthetic improvement using the global aesthetic improvement scale (GAIS). Results Eighteen subjects completed the study. Superior GAIS results were achieved on the ALA‐PDT + IPL treatment side than on the ALA‐PDT only treatment side (p < 0.001) after 24 weeks of follow‐up. Conclusions ALA‐PDT using 10% ALA hydrochloride gel and BF‐RhodoLED® light had superior rejuvenation effects on the décolleté when combined with IPL compared to ALA‐PDT alone.
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ISSN:0196-8092
1096-9101
1096-9101
DOI:10.1002/lsm.23460