Peritoneal carcinomatosis in gastric cancer: Are Hispanics at higher risk?

• Published in: Journal of surgical oncology Vol. 122; no. 8; pp. 1624 - 1629
• Main Authors: Choi, Audrey H., Ji, Liang, Babcock, Blake, Ramos, Vicente, Kwong, Mei Li M., Morgan, John W., Selleck, Matthew J., Langridge, William H. R., DeLeon, Marino, Wall, Nathan R., Lum, Sharon, Pigazzi, Alessio, Dayyani, Farshid, Senthil, Maheswari
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2020
• Subjects: Adenocarcinoma - epidemiology; Adenocarcinoma - secondary; Adult; African Americans - statistics & numerical data; Aged; California - epidemiology; epidemiology; Ethnicity; European Continental Ancestry Group - statistics & numerical data; Female; Follow-Up Studies; Gastric cancer; Hispanic; Hispanic Americans - statistics & numerical data; Hispanic people; Humans; Incidence; Male; Middle Aged; peritoneal carcinomatosis; Peritoneal Neoplasms - epidemiology; Peritoneal Neoplasms - secondary; Prognosis; Registries; Risk Factors; Stomach Neoplasms - epidemiology; Stomach Neoplasms - pathology; Young Adult; California; epidemiology; gastric cancer; Hispanic; peritoneal carcinomatosis
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.26210

Background A recent study from our group identified Hispanic race/ethnicity as an independent predictor of peritoneal carcinomatosis (PC) in gastric cancer. We sought to identify the tumor factors that might contribute to this strong association in Hispanics. Methods California Cancer Registry data were used to identify patients diagnosed with gastric adenocarcinoma from 2004 to 2014. Logistic regression analyses were performed to determine odds ratios for cancer stage, tumor location, grade, histology, and PC. Results Of 16,275 patients with gastric adenocarcinoma who met inclusion criteria, 6463 (39.7%) were non‐Hispanic White (NHW), 4953 (30.4%) were Hispanic, 1020 (6.3%) were non‐Hispanic Black (NHB), and 3915 (23.6%) were Asian/other. Compared to NHW, Hispanics were more likely to have a poorly differentiated grade (65.9% vs. 57.6%; p < .001), signet ring adenocarcinoma (28.1% vs. 17.6%; p < .001) and stage IV (51.9% vs. 45.0%; p < .001) gastric cancer. The proportion of stage IV patients with PC was also significantly higher in Hispanics compared to NHW, NHB, and Asian/other (28.5% vs. 16.6%, 20.5%, and 25.2%, respectively; p < .001). Conclusions Hispanic ethnicity is an independent predictor of aggressive tumor phenotype and PC. Disproportionate incidence of signet ring adenocarcinoma and PC highlight the need to explore the genomic differences in Hispanic gastric cancer.