Syntheses of furo[3,4-c]coumarins and related furyl coumarin derivatives via intramolecular Wittig reactions

A new and general strategy for highly functional furo[3,4-c]coumarins and related furyl coumarin derivatives has been developed, which is based on an extraordinarily facile intramolecular Wittig reaction, starting from alpha,beta-unsaturated ketones, tributylphosphine, and acyl chlorides. The phosph...

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Published inOrganic & biomolecular chemistry Vol. 10; no. 4; pp. 843 - 847
Main Authors Jang, Yeong-Jiunn, Syu, Siang-en, Chen, Yu-Jhang, Yang, Mei-Chun, Lin, Wenwei
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 28.01.2012
Subjects
Chemistry
Chemistry Techniques, Synthetic - economics
Chemistry Techniques, Synthetic - methods
Chemistry, Organic
Chlorides - chemistry
Furans - chemical synthesis
Furans - chemistry
Furocoumarins - chemical synthesis
Furocoumarins - chemistry
Ketones - chemistry
Phosphines - chemistry
Photosensitizing Agents - chemical synthesis
Photosensitizing Agents - chemistry
Physical Sciences
Science & Technology
FUROCOUMARINS
BIOLOGICAL-ACTIVITY
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Summary:A new and general strategy for highly functional furo[3,4-c]coumarins and related furyl coumarin derivatives has been developed, which is based on an extraordinarily facile intramolecular Wittig reaction, starting from alpha,beta-unsaturated ketones, tributylphosphine, and acyl chlorides. The phosphorus ylides were proposed to be the key intermediates for constructing the crucial furan ring, leading to a wide variety of substituted furyl coumarins in one step.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1477-0520
1477-0539
DOI:10.1039/c1ob06571h