Paternity investigation experience with a 40 autosomal SNP panel

With both the SNP forID and the Kidd panels of autosomal SNPs available, we selected the 40 most informative and population-independent SNPs from both these sets for evaluation in paternity testing and as a prelude for forensic human identification. We used the published primer sequences and constru...

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Bibliographic Details
Published inForensic science international. Genetics supplement series Vol. 2; no. 1; pp. 149 - 150
Main Authors Whittle, M.R., Favaro, E.C., Sumita, D.R.
Format Journal Article
LanguageEnglish
Published Elsevier Ireland Ltd 01.12.2009
Subjects
Autosomal SNP
Parentage testing
Parentage testing
Autosomal SNP
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Summary:With both the SNP forID and the Kidd panels of autosomal SNPs available, we selected the 40 most informative and population-independent SNPs from both these sets for evaluation in paternity testing and as a prelude for forensic human identification. We used the published primer sequences and constructed PCR multiplexes for genotyping using the SNaPshot assay. Fifty trios and 50 duos previously analysed using conventional autosomal STR markers were re-analysed using the 40 SNPs. We report our findings regarding the practical use of these markers including unexpected mutations which impacted significantly on the use of this panel.
ISSN:1875-1768
1875-175X
DOI:10.1016/j.fsigss.2009.08.056