Synthesis of spirooxindolocarbamates based on Betti reaction: antibacterial, antifungal and antioxidant activities
A series of new spirooxindolocarbamates 4a–l and 6a–d were synthesized by using the Betti reaction. All the target compounds were well characterized by IR, NMR and mass spectrometry. The structures of the compounds 4a and 4e were confirmed by the single crystal X-ray diffraction. The in vitro antiba...
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Published in | Molecular diversity Vol. 24; no. 4; pp. 1139 - 1147 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Cham
Springer International Publishing
01.11.2020
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | A series of new spirooxindolocarbamates
4a–l
and
6a–d
were synthesized by using the Betti reaction. All the target compounds were well characterized by IR, NMR and mass spectrometry. The structures of the compounds
4a
and
4e
were confirmed by the single crystal X-ray diffraction. The in vitro antibacterial activity results revealed that the compounds
4f
exhibited excellent antibacterial activity against
E. coli
with MIC value 7.5 µg/mL when compared with the standard drug ciprofloxacin with MIC value 9.25 µg/mL. The compounds
4l
and
6c
exhibit significant inhibiting activity against
E. Coli
with MIC values 10.5 µg/mL and 9.5 µg/mL, respectively. The compounds
4c
and
4e
showed significant activity against
S. aureus
with MIC value 10.5 µg/mL. The compounds
4a
and
4f
were exhibited moderate antifungal activity against
A. niger
with MIC values 17.5 µg/mL and 18.0 µg/mL, respectively. The compounds
4f
and
4l
exhibited the potent antioxidant activity with IC
50
values 9.12 ± 0.01 µM and 7.06 ± 0.78 µM, respectively.
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1381-1991 1573-501X |
DOI: | 10.1007/s11030-019-10017-w |