The imbalance of IL-18/IL-18BP in patients with systemic juvenile idiopathic arthritis

Systemic ,IIA （SJIA） is one subtype of juvenile idiopathic arthritis （jrlA） that is a leading cause of short-term and long-term disability in children [1]. Although SJIA repre- sents only 10%-20% of all cases of JIA, it accounts for more than two-thirds of the mortality associated with this conditio...

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Published inActa biochimica et biophysica Sinica Vol. 45; no. 4; pp. 339 - 341
Main Authors Chen, Ou, Shan, Ningning, Zhu, Xiaobo, Wang, Yibiao, Ren, Peng, Wei, De'e, Sun, Ruopeng
Format Journal Article
LanguageEnglish
Published China 01.04.2013
Subjects
Adolescent
Arthritis, Juvenile - blood
Arthritis, Juvenile - genetics
Arthritis, Juvenile - pathology
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infant
Intercellular Signaling Peptides and Proteins - blood
Intercellular Signaling Peptides and Proteins - genetics
Interleukin-18 - blood
Interleukin-18 - genetics
Leukocytes, Mononuclear - metabolism
Male
Reverse Transcriptase Polymerase Chain Reaction
不平衡
关节炎
发病机制
幼年
患者
条件相关
死亡率
残疾儿童
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Summary:Systemic ,IIA （SJIA） is one subtype of juvenile idiopathic arthritis （jrlA） that is a leading cause of short-term and long-term disability in children [1]. Although SJIA repre- sents only 10%-20% of all cases of JIA, it accounts for more than two-thirds of the mortality associated with this condition [2]. The etiology and pathogenesis of SJIA remain urd~nown. Further understanding of SJIA pathogen- esis may fiicilitate new therapeutic approaches.
Bibliography:31-1940/Q
Systemic ,IIA （SJIA） is one subtype of juvenile idiopathic arthritis （jrlA） that is a leading cause of short-term and long-term disability in children [1]. Although SJIA repre- sents only 10%-20% of all cases of JIA, it accounts for more than two-thirds of the mortality associated with this condition [2]. The etiology and pathogenesis of SJIA remain urd~nown. Further understanding of SJIA pathogen- esis may fiicilitate new therapeutic approaches.
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ISSN:1672-9145
1745-7270
DOI:10.1093/abbs/gmt007