Synthesis and antimicrobial properties of cycloheptyl substituted benzimidazolium salts and their silver(I) carbene complexes

• Published in: Heterocyclic communications Vol. 22; no. 6; pp. 357 - 361
• Main Authors: Karataş, Mert Olgun, Günal, Selami, Mansur, Ahmet, Alıcı, Bülent, Çetinkaya, Engin
• Format: Journal Article
• Language: English
• Published: Berlin De Gruyter 01.12.2016; Walter de Gruyter GmbH
• Subjects: Antiinfectives and antibacterials; antimicrobial; Antimicrobial agents; Bacteria; benzimidazole; Carbenes; Chemical analysis; Chemical synthesis; cycloheptyl; Dichloromethane; E coli; Fungi; Gram-positive bacteria; heterocyclic carbine; NMR; Nuclear magnetic resonance; Pseudomonas aeruginosa; Room temperature; silver; Silver compounds
• ISSN: 0793-0283; 2191-0197
• DOI: 10.1515/hc-2016-0105

Due to increasing infections caused by microbes, there is an urgent need for the development of new effective antimicrobial agents. Silver- -heterocyclic carbene (silver-NHC) complexes are a new class of antimicrobial agents. In this study, we aimed to synthesize highly lipophilic silver-NHC complexes. Four new complexes were synthesized by the reaction of the corresponding benzimidazolium salts and Ag O in dichloromethane at room temperature. The synthesized compounds were characterized by H NMR, C NMR, IR and elemental analysis. The antimicrobial performances of benzimidazolium salts and silver complexes were tested against the standard bacterial strains , , , and the fungi and . Minimum inhibitory concentrations (MICs) of all compounds were determined. The obtained data demonstrate that all benzimidazolium salts and silver complexes inhibit the growth of bacteria and fungi. Silver complexes are more active than the corresponding benzimidazolium salts (MIC: 6.25 μg/mL for Gram-positive bacteria and fungi).