Synthesis, spectral characterization and biological activity of zinc(II) complexes with 3-substituted phenyl-4-amino-5-hydrazino-1, 2, 4-triazole Schiff bases

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 85; no. 1; pp. 1 - 6
• Main Authors: Singh, A.K., Pandey, O.P., Sengupta, S.K.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.01.2012
• Subjects: 13C NMR; 1H NMR; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antifungal Agents - chemical synthesis; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Antifungal and antibacterial; Bacteria - drug effects; Bacterial Infections - drug therapy; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; FT-IR; Fungi - drug effects; Humans; Microbial Sensitivity Tests; Mycoses - drug therapy; Schiff bases; Schiff Bases - chemical synthesis; Schiff Bases - chemistry; Schiff Bases - pharmacology; Triazoles - chemical synthesis; Triazoles - chemistry; Triazoles - pharmacology; Zinc - chemistry; Zinc - pharmacology; Zn(II); Zn(II); Schiff bases; FT-IR; 1H NMR; 13C NMR; Antifungal and antibacterial
• ISSN: 1386-1425; 1873-3557
• DOI: 10.1016/j.saa.2011.08.019

Zinc(II) complexes with 3-substituted phenyl-4-amino-5-hydrazino-1, 2, 4-triazole Schiff bases have been synthesized and characterized. Their microbial activities have been evaluated. [Display omitted] ► The zinc(II) complexes were synthesized by multi-step reactions and characterized. ► Zinc(II) complexes show significant antifungal and antibacterial activity. ► These zinc(II) complexes offer possibility for new type of economically affordable pesticides. New Zn(II) complexes have been synthesized by the reactions of zinc(II) acetate with Schiff bases derived from 3-substituted phenyl-4-amino-5-hydrazino-1, 2, 4-triazole and benzaldehyde, 2-hydroxyacetophenone or indoline-2,3-dione. All these complexes are soluble in DMF and DMSO; low molar conductance values indicate that they are non-electrolytes. Elemental analyses suggest that the complexes have 1:1 stoichiometry of the type [ZnL(H 2O) 2], [ZnL′(OAc) 2(H 2O) 2] (L = dianionic Schiff bases derived from 3-(substituted phenyl)-4-amino-5-hydrazino-1, 2, 4-triazole and 2-hydroxyacetophenone or indoline-2,3-dione; L′ = neutral Schiff bases derived from 3-(substituted phenyl)-4-amino-5-hydrazino-1, 2, 4-triazole and benzaldehyde) and they were characterized by FT-IR, 1H NMR, 13C NMR and FAB mass. All these Schiff bases and their complexes have also been screened for their antibacterial activities against Bacillus subtilis, Escherichia coli and antifungal activities against Colletotrichum falcatum, Aspergillus niger, Fusarium oxysporium and Carvularia pallescence by petriplates methods.