A manganese dioxide nanoparticle–bimetallic metal organic framework composite for selective and sensitive detection of vitamin D3 in human plasma

For the first time a metal organic framework nanomaterial has been developed comprising manganese dioxide nanoparticle and iron and zinc metal ions interlinked with each other via terephthalic acid. The framework shape was identified as an elongated hexagonal nanorod (TEM) with varying functional gr...

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Published inMikrochimica acta (1966) Vol. 190; no. 9; p. 345
Main Authors Lokesh Kumar, S, Kumar, Sanjit, Tetala, Kishore K. R.
Format Journal Article
LanguageEnglish
Published Vienna Springer Vienna 01.09.2023
Springer Nature B.V
Subjects
Analytical Chemistry
Bimetals
Blood plasma
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Coated electrodes
Diffraction patterns
Electrolytes
Functional groups
Manganese dioxide
Metal-organic frameworks
Microengineering
Nanochemistry
Nanocomposites
Nanomaterials
Nanoparticles
Nanorods
Nanotechnology
Original Paper
Sulfuric acid
Terephthalic acid
Metal organic framework
Cyclic voltammetry
Plasma samples
Vitamin D
nanoparticle
Modified glassy carbon electrode
Electrochemical sensor
MnO
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Summary:For the first time a metal organic framework nanomaterial has been developed comprising manganese dioxide nanoparticle and iron and zinc metal ions interlinked with each other via terephthalic acid. The framework shape was identified as an elongated hexagonal nanorod (TEM) with varying functional groups (FT-IR) and diffraction patterns (XRD). The framework nanocomposite as such in aqueous acidic electrolyte solution has displayed an excellent conductivity (redox behavior) and surface excess (3.08 × 10 −8 cm −2 ). Under the optimized conditions (0.1 M H 2 SO 4 as electrolyte, 50 mV/s scan rate, +1.26 V (vs Ag/AgCl)), the metal organic framework coated electrode has selectively identified vitamin D 3 (VD 3 ) in the presence of various other interfering molecules and displayed excellent limit of detection (1.9 ng mL −1 ). The developed sensor has been applied to the determination of VD 3 in extracted human plasma samples (RSD of 0.3–2.6 % and recovery of 96–102 %), and the obtained VD3 values are similar to HPLC-UV method. Graphical abstract
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ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-023-05904-x