Evaluation of systemic immune-inflammation index level as a novel marker for severity of noninfectious uveitis

Purpose To evaluate the association of systemic immune-inflammation index (SII) levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) with severity of noninfectious uveitis. Methods This retrospective study included 46 patients with noninfectious uveitis (uveitis group) and...

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Published inInternational ophthalmology Vol. 41; no. 11; pp. 3615 - 3622
Main Authors Kurtul, Bengi Ece, Cakmak, Ayse Idil, Elbeyli, Ahmet, Ozcan, Sait Coskun, Ozarslan Ozcan, Deniz, Kimyon, Gezmis
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.11.2021
Springer Nature B.V
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Summary:Purpose To evaluate the association of systemic immune-inflammation index (SII) levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) with severity of noninfectious uveitis. Methods This retrospective study included 46 patients with noninfectious uveitis (uveitis group) and 46 age- and sex-matched healthy subjects (control group). The demographic and ocular findings, localization, and activity of uveitis were recorded at the time of onset evaluation. SII, NLR, and PLR levels of patients were compared between the groups. Results SII, NLR, and PLR levels were significantly higher in uveitis group when compared to control group ( p  < 0.001, p  = 0.005, and p  = 0.001, respectively). While SII and NLR were significantly higher in severe anterior uveitis than mild anterior uveitis ( p  = 0.006 and p  = 0.021, respectively), only SII was significantly higher in severe posterior and panuveitis than mild ones ( p  = 0.038). Conclusion SII, as a novel inflammation index, may be more significant tool than NLR and PLR in determining the severity of the uveitis. Furthermore, SII may be a potential useful index in clinical practice to follow-up and manage these patients by monitoring response to anti-inflammatory treatment modalities.
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ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-021-01924-9