Involvement of 5-lipoxygenase in Alzheimer's disease: a role for DNA methylation

Lipoxygenases play a major role in the neuropathology of Alzheimer's disease (AD), even though the underlying mechanisms are as yet poorly understood. Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of subjects with late-onset AD and ag...

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Published inJournal of Alzheimer's disease Vol. 37; no. 1; p. 3
Main Authors Di Francesco, Andrea, Arosio, Beatrice, Gussago, Cristina, Dainese, Enrico, Mari, Daniela, D'Addario, Claudio, Maccarrone, Mauro
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2013
Subjects
Aged
Aged, 80 and over
Alzheimer Disease - diagnosis
Alzheimer Disease - enzymology
Arachidonate 5-Lipoxygenase - biosynthesis
DNA Methylation - physiology
Female
Follow-Up Studies
Humans
Leukocytes, Mononuclear - enzymology
Male
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Summary:Lipoxygenases play a major role in the neuropathology of Alzheimer's disease (AD), even though the underlying mechanisms are as yet poorly understood. Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of subjects with late-onset AD and age-matched controls. We found a significant increase in 5-LOX gene expression in AD subjects compared to healthy controls, paralleled by increased 5-LOX protein and leukotriene B4, the 5-LOX product. In addition, a consistent reduction in DNA methylation at 5-LOX gene promoter was documented in AD versus healthy subjects. Taken together, our findings further support a role for 5-LOX in vulnerability to neurodegeneration.
ISSN:1875-8908
DOI:10.3233/JAD-130506