Ionic liquid promoted synthesis of heterocycle-fused pyrimidine-2,4(1H,3H)-diones utilising CO2

[Display omitted] •CO2 as carbon source for heterocycle synthesis.•Generalized for the synthesis of heterocycle-fused pyrimidine-2,4(1H,3H)-diones.•The synthesis method was green, simple and substrate scope compatibility. An efficient ionic liquid system was developed for the preparation of various...

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Bibliographic Details
Published inTetrahedron letters Vol. 59; no. 25; pp. 2463 - 2466
Main Authors Li, Chun, Lu, Xunhua, Yang, Yuanyong, Yang, Shenggang, Zhang, Lin
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 20.06.2018
Elsevier
Subjects
Carbon dioxide
Chemistry
Chemistry, Organic
Green chemistry
Heterocycles
Ionic liquid
Physical Sciences
Pyrimidine-2,4(1H,3H)-diones
Science & Technology
Heterocycles
Green chemistry
Pyrimidine-2,4(1H,3H)-diones
Carbon dioxide
Ionic liquid
DESIGN
QUINAZOLINE-2,4(1H,3H)-DIONES
EFFICIENT SYNTHESIS
CATALYTIC AMOUNT
INHIBITORS
2-AMINOBENZONITRILES
CARBON-DIOXIDE
DERIVATIVES
ATMOSPHERIC-PRESSURE
SOLVENT-FREE SYNTHESIS
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Summary:[Display omitted] •CO2 as carbon source for heterocycle synthesis.•Generalized for the synthesis of heterocycle-fused pyrimidine-2,4(1H,3H)-diones.•The synthesis method was green, simple and substrate scope compatibility. An efficient ionic liquid system was developed for the preparation of various heterocycle-fused pyrimidine-2, 4(1H,3H)-diones in moderate to excellent yields (52–95%). It was found that [HDBN+][TFE−], a simple and easily prepared ionic liquid, could act as both the solvent and reaction promoter, and that the reactions could be efficiently carried out at atmospheric pressures of CO2.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2018.05.043