A fibrin patch loaded with mesenchymal stem cells-derived exosomes improves cardiac functions after myocardial infarction

• Published in: Colloid and interface science communications Vol. 59; p. 100775
• Main Authors: Wang, Xiaoyu, Wang, Jingjing, Zhang, Yanxia, Yu, Yunsheng, Shen, Zhenya
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2024
• Subjects: Exosomes; Fibrin patch; Mesenchymal stem cells; Myocardial infarction; Myocardial infarction; Fibrin patch; Exosomes; Mesenchymal stem cells
• ISSN: 2215-0382; 2215-0382
• DOI: 10.1016/j.colcom.2024.100775

Myocardial infarction (MI) is a typical cardiovascular disease, causing disability and death worldwide. Exosomes secreted by mesenchymal stem cells (MSCs) showed remarkable therapeutic effects in MI by restoring cardiac function. However, the application of exosomes remains a challenge because of their low residence rate in the infarcted myocardium. Herein, a fibrin-based cardiac patch was prepared to deliver MSCs-derived exosomes to the infarcted heart using an MI mouse model, aiming at improvement of cardiac functions. The fibrin patch was optimized for size to minimize the mouse mortality rate. The composite patch showed sustained release of exosomes in vitro and could improve the retention of exosomes in the infarcted heart, inhibiting fibrosis and improving cardiac functions in vivo. Therefore, this combination of natural biomaterial-based cardiac patch and MSCs-derived exosomes may have a promising clinical translational potential for the MI treatment. [Display omitted] •A fibrin-based cardiac patch is developed to deliver exosomes to the infarcted heart.•Implantation of this patch improves cardiac function after myocardial infarction.•The myocardial infarction mice implanted with the 3.5 mm-diameter fibrin patch show the highest survival rate.