Synthesis of a MUC1-glycopeptide-BSA conjugate vaccine bearing the 3 '-deoxy-3 '-fluoro-Thomsen-Friedenreich antigen

A novel MUC1-glycopeptide-BSA conjugate vaccine with a specifically fluorinated Thomsen-Friedenreich antigen side chain at Thr6 was prepared. Preliminary immunological experiments reveal specific binding of the tumor-associated glycopeptide antigen analog by anti-MUC1-mouse antibodies.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 47; no. 35; pp. 9903 - 9905
Main Authors Hoffmann-Roeder, Anja, Johannesy, Manuel
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.09.2011
Subjects
Animals
Antigens, Tumor-Associated, Carbohydrate - chemistry
Antigens, Tumor-Associated, Carbohydrate - immunology
Antigens, Tumor-Associated, Carbohydrate - metabolism
Cattle
Chemistry
Chemistry, Multidisciplinary
Glycopeptides - metabolism
Mice
Mucin-1 - metabolism
Physical Sciences
Science & Technology
Serum Albumin, Bovine - metabolism
Vaccines, Conjugate - chemistry
Vaccines, Conjugate - immunology
Vaccines, Conjugate - metabolism
TANDEM REPEAT SEQUENCE
GLYCOPEPTIDE ANTIGEN
RESPONSES
MUC1 GLYCOPEPTIDES
ANTITUMOR VACCINES
ANTIBODY
TUMOR-ASSOCIATED CARBOHYDRATE
INDUCTION
IDENTIFICATION
BINDING
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Summary:A novel MUC1-glycopeptide-BSA conjugate vaccine with a specifically fluorinated Thomsen-Friedenreich antigen side chain at Thr6 was prepared. Preliminary immunological experiments reveal specific binding of the tumor-associated glycopeptide antigen analog by anti-MUC1-mouse antibodies.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc13184b