Citric acid-crosslinked β-cyclodextrin supported zinc peroxide as a biocompatible H2O2 scavenger

• Published in: Journal of biological inorganic chemistry Vol. 25; no. 3; pp. 411 - 417
• Main Authors: Pirouzmand, Mahtab, Sani, Parya Salahshour, Ghasemi, Zarrin, Azizi, Sajjad
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2020; Springer Nature B.V
• Subjects: Acids; Biochemistry; Biomedical and Life Sciences; Citric acid; Cytotoxicity; Hydrogen peroxide; Inorganic chemistry; Life Sciences; Microbiology; Original Paper; Radiation; β-Cyclodextrin; β-Cyclodextrin; Ultrasonication; H; Biocompatible; ZnO; scavenger; Antioxidant; O
• ISSN: 0949-8257; 1432-1327
• DOI: 10.1007/s00775-020-01771-6

The aim of the present study was to evaluate the H 2 O 2 scavenging activity of the ZnO 2 /β-CD as a biocompatible composite. Zinc peroxide was prepared via sonochemical approach. To synthesize a green composite, β-cyclodextrin was modified by citric acid (CA) and reacted with ZnO 2 under ultrasonic irradiation. The prepared samples were characterized using XRD, SEM, TGA and FTIR analytical techniques. XRD analysis exhibited a typical pattern of ZnO 2 and demonstrated the presence of citric acid and β-cyclodextrin in composite. The results of the catalytic assay showed that the ZnO 2 /CA-βCD composite displayed stronger capability to decompose H 2 O 2 in comparison to ZnO 2 particles (about seven times). It was attributed to increased adsorption capacity and solubility of composite due to the presence of citric acid and β-cyclodextrin. MTT assay studies confirmed the non-cytotoxic nature of ZnO 2 particles and ZnO 2 /CA-βCD composite. Graphic abstract