The association of gamma-glutamyltransferase and C-reactive protein with IFG/IGT in Chinese adults in Qingdao, China

• Published in: Clinica chimica acta Vol. 412; no. 17-18; pp. 1658 - 1661
• Main Authors: Sun, Jianping, Ren, J., Pang, Z.C., Gao, W.G., Nan, H.R., Wang, S.J., Zhang, L., Qiao, Q.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 17.08.2011
• Subjects: Adult; Aged; C-reactive protein; C-Reactive Protein - metabolism; China; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Female; Gamma-glutamyltransferase; gamma-Glutamyltransferase - metabolism; Glucose Tolerance Test; Humans; Impaired fasting glucose; Impaired glucose tolerance; Male; Middle Aged; China; Impaired fasting glucose; C-reactive protein; Gamma-glutamyltransferase; Impaired glucose tolerance
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2011.05.019

Serum gamma-glutamyltransferase (GGT) and C-reactive protein(CRP) have been previously shown to be associated with impaired fasting glucose/impaired glucose tolerance (IFG/IGT), but such an association has not been well verified, and is examined in a non-diabetic Chinese population. A population-based cross-sectional study was conducted in 2006 in Qingdao, China. Data of 1143 men and 1689 women aged 35–74years and free of diabetes at baseline were analyzed. Multivariable logistic regression analysis was performed to estimate the odds ratio (OR) and its 95% confidence interval (CI). Compared with the lowest quartile, the ORs (95%CI) for IFG/IGT corresponding to the highest quartile were 0.89(0.61,1.28) in men and 0.87(0.64,1.18) in women for CRP and 2.12(1.40,3.38) and 1.87(1.32,2.62) for GGT, when the two were fitted simultaneously in a model adjusting for age, school years, alcohol-drinking, smoking, family history of diabetes, systolic blood pressure, waist circumference, triglycerides and high-density lipoprotein. The elevated GGT, but not CRP, was independently associated with the presence of the IFG/IGT in both genders in this Chinese population.