Free radicals and muscle damage

Muscle tissue is unique in its requirement and ability to undertake very rapid and co-ordinated changes in energy supply and oxygen flux during contraction. Several studies have suggested that this renders the tissue particularly prone to oxygen radical-mediated damage. Free radicals have been postu...

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Bibliographic Details
Published inBritish medical bulletin Vol. 49; no. 3; p. 630
Main Authors Jackson, M J, O'Farrell, S
Format Journal Article
LanguageEnglish
Published England 01.07.1993
Subjects
Animals
Antioxidants - therapeutic use
Exercise - physiology
Free Radicals - metabolism
Humans
Lipid Peroxidation
Muscles - metabolism
Muscular Diseases - drug therapy
Muscular Diseases - metabolism
Rats
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Summary:Muscle tissue is unique in its requirement and ability to undertake very rapid and co-ordinated changes in energy supply and oxygen flux during contraction. Several studies have suggested that this renders the tissue particularly prone to oxygen radical-mediated damage. Free radicals have been postulated to play a role in muscle damage induced by different forms of exercise and in various pathological disorders, such as the muscular dystrophies, malignant hyperthermia and alcoholic myopathy. However, conclusive evidence for a fundamental role for free radicals and protective effect of antioxidants remains elusive in all these situations and much further work on the relevant pathogenetic mechanisms is still required.
ISSN:0007-1420
DOI:10.1093/oxfordjournals.bmb.a072636