Interspecies differences in clinical characteristics and risk factors for third-generation cephalosporin resistance between Escherichia coli and Klebsiella pneumoniae bloodstream infection in patients with liver cirrhosis

• Published in: European journal of clinical microbiology & infectious diseases Vol. 41; no. 12; pp. 1459 - 1465
• Main Authors: Ham, Sin Young, Jung, Hyungul, Song, Kyoung-Ho, Jeong, Hyeonju, Jung, Jongtak, Moon, Song Mi, Park, Jeong Su, Kim, Nak-Hyun, Jang, Eun Sun, Kim, Jin-Wook, Jeong, Sook-Hyang, Kim, Eu Suk, Kim, Hong Bin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2022; Springer Nature B.V
• Subjects: Amides; Antibiotics; Biomedical and Life Sciences; Biomedicine; Brief Report; Catheters; Cephalosporins; Cirrhosis; Comorbidity; E coli; Electronic health records; Escherichia coli; Failure rates; Hospitals; Infectious diseases; Internal Medicine; Klebsiella; Klebsiella pneumoniae; Liver; Liver cirrhosis; Liver diseases; Medical Microbiology; Medical records; Medicine; Mortality; Nosocomial infection; Nosocomial infections; Patients; Resistance factors; Risk analysis; Risk factors; β-Lactam antibiotics; Interspecies difference; Bloodstream infection; Third-generation cephalosporin resistance; Liver cirrhosis; Mortality; Enterobacteriaceae
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s10096-022-04508-2

This retrospective study aimed to clarify the interspecies differences in the clinical characteristics and risk factors of bloodstream infection (BSI) due to third-generation cephalosporin-resistant (3GC-R) Escherichia coli (EC) and Klebsiella pneumoniae (KP) in patients with liver cirrhosis (LC). KP BSI had more comorbidities and higher treatment failure rate than EC BSI. Non-alcoholic LC was a risk factor for treatment failure in EC, whereas it was not associated with KP. Risk factors for BSI due to 3GC-R strain were nosocomial infection in EC, and β-lactam/fluoroquinolone treatment ≤ 30 days in KP. These results could help predict outcomes of BSI and improve clinical practice.