A novel method for the synthesis of 1-aryltetrahydroisoquinolines
[Display omitted] •A brief and less limited approach relative to the Pictet-Spengler method to 1-aryltetrahydroisoquinolines.•A variety of contrasting routes are available for precursor synthesis.•Chiral, non-racemic products should be available from this method. Carbenium ions generated from substi...
Saved in:
Published in | Tetrahedron letters Vol. 58; no. 4; pp. 294 - 297 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
25.01.2017
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | [Display omitted]
•A brief and less limited approach relative to the Pictet-Spengler method to 1-aryltetrahydroisoquinolines.•A variety of contrasting routes are available for precursor synthesis.•Chiral, non-racemic products should be available from this method.
Carbenium ions generated from substituted benzhydryls using acid catalysis undergo smooth intramolecular trapping by pendant sulfonamide groups to provide excellent yields of 1-aryltetrahydroisoquinolines. |
---|---|
ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2016.11.115 |