Association between Helicobacter pylori infection and metabolic dysfunction-associated steatohepatitis: From an analysis of a population-based study

• Published in: World journal of hepatology Vol. 17; no. 2; p. 102734
• Main Author: Zhao, Cheng-Fei
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 27.02.2025
• Subjects: Letter to the Editor; Metabolic dysfunction-associated steatohepatitis; Innovative research directions; Helicobacter pylori infection; Metabolic dysfunction-associated steatotic liver disease; Non-alcoholic fatty liver disease
• ISSN: 1948-5182; 1948-5182
• DOI: 10.4254/wjh.v17.i2.102734

The growing global burden of metabolic dysfunction-associated steatohepatitis (MASH) demands a deeper understanding of its underlying mechanisms and risk factors. Recent studies, such as the large population-based case-control analysis by Abdel-Razeq et al , suggest a significant association between Helicobacter pylori (H. pylori) infection and an increased risk of developing MASH. This study provides compelling data supporting this association, even after adjusting for confounders such as obesity, diabetes, and hyperlipidemia. However, the complexity of this relationship remains unresolved, requiring further investigation into the biological, genetic, and environmental pathways that connect these two conditions. This article critically reviews the study’s findings and identifies its limitations, offering innovative research directions for the future. Key areas of focus include integrating genomic and microbiome analyses, exploring the impact of H. pylori eradication on MASH progression, studying molecular mechanisms at the intersection of infection and liver disease, and developing personalized therapeutic strategies.