In situ forming mesoporous polydopamine nanocomposite thermogel for combined chemo-photothermal therapy of intraocular cancer

• Published in: Colloid and interface science communications Vol. 54; p. 100715
• Main Authors: Tao, Chunwen, Huang, Yate, Chen, Junrong, Peng, Qiaohua, Nan, Kaihui, Chen, Yangjun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.05.2023
• Subjects: Combined chemo-photothermal therapy; Hexanoyl glycol chitosan; Intraocular cancer; Mesoporous polydopamine nanoparticles; Thermogel; Combined chemo-photothermal therapy; Intraocular cancer; Hexanoyl glycol chitosan; Thermogel; Mesoporous polydopamine nanoparticles
• ISSN: 2215-0382; 2215-0382
• DOI: 10.1016/j.colcom.2023.100715

Intraocular cancers such as retinoblastoma and uveal melanoma will induce severe vision loss or even death. Herein, a versatile nanocomposite thermogel based on hexanoyl glycol chitosan (HGC) and mesoporous polydopamine nanoparticles (MPDA NPs) was designed for potential use as an intraocular “drug depot” for the treatment of intraocular tumors. The integrated HGC-MPDA thermogel showed reversible sol-gel transition property as well as injectable and in-situ gelation abilities. The incorporated MPDA NPs endowed the thermogel with outstanding NIR laser-based photothermal conversion ability and enabled NIR light-controlled drug release. Moreover, in vitro study revealed that drug-loaded thermogel (HGC-MPDA@DOX) with the aid of 808 nm laser irradiation possessed superior anticancer effect than any single treatment via synergistic chemo-photothermal therapy. The present study demonstrated that HGC-MPDA could serve as a multifunctional platform for sustained and NIR light-responsive intravitreal drug delivery, avoiding repetitive injection, and the localized chemo-photothermal therapy provides a promising strategy against intraocular tumors. [Display omitted] •An in situ forming nanocomposite thermogel (HGC-MPDA) was successfully fabricated.•The nanocomposite thermogel showed good reversible sol-gel transition, injectable, and photothermal conversion properties.•Doxorubicin-loaded nanocomposite thermogel with NIR laser irradiation could effectively kill OCM-1 cancer cells.