Analysis of Field-Effect Biosensors using Self-Consistent 3D Drift-Diffusion and Monte-Carlo Simulations

Field-effect biosensors based on nanowires enjoy considerable popularity due to their high sensitivity and direct electrical readout [1]. However, crucial issues such as the influence of the biomolecules on the charge-carrier transport or the binding of molecules to the surface have not been describ...

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Bibliographic Details
Published inProcedia engineering Vol. 25; pp. 407 - 410
Main Authors Baumgartner, S., Vasicek, M., Bulyha, A., Tassotti, N., Heitzinger, C.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2011
Subjects
field-effect biosensors
field-effect DNA sensors
sensor simulation
silicon nanowire
silicon nanowire
sensor simulation
field-effect DNA sensors
field-effect biosensors
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Summary:Field-effect biosensors based on nanowires enjoy considerable popularity due to their high sensitivity and direct electrical readout [1]. However, crucial issues such as the influence of the biomolecules on the charge-carrier transport or the binding of molecules to the surface have not been described satisfactorily yet in a quantitative manner. In order to analyze these effects, we present simulation results based on a 3D macroscopic transport model coupled with Monte-Carlo simulations for the bio-functionalized surface layer. Excellent agreement with measurement data has been found, while detailed study of the influence of the most prominent biomolecules, namely double-stranded DNA and single-stranded DNA, on the current through the semiconductor transducer has been carried out.
ISSN:1877-7058
1877-7058
DOI:10.1016/j.proeng.2011.12.101