Enantioselective organocatalytic asymmetric allylic alkylation. Bis(phenylsulfonyl)methane addition to MBH carbonates

The highly enantioselective asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates with bis(phenylsulfonyl)methane is presented. The reaction is simply catalyzed by cinchona alkaloid derivatives affording the final alkylated products in good yields and enantioselectivities.

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 9; no. 23; pp. 7986 - 7989
Main Authors Companyo, Xavier, Valero, Guillem, Ceban, Victor, Calvet, Teresa, Font-Bardia, Merce, Moyano, Albert, Rios, Ramon
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.12.2011
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
KINETIC RESOLUTION
ANION
ALPHA,BETA-UNSATURATED ALDEHYDES
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Summary:The highly enantioselective asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates with bis(phenylsulfonyl)methane is presented. The reaction is simply catalyzed by cinchona alkaloid derivatives affording the final alkylated products in good yields and enantioselectivities.
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ISSN:1477-0520
1477-0539
DOI:10.1039/c1ob06308a