Influence of comorbid depression on fear in posttraumatic stress disorder: An fMRI study

Abstract Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal–amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced i...

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Bibliographic Details
Published inPsychiatry research. Neuroimaging Vol. 155; no. 3; pp. 265 - 269
Main Authors Kemp, Andrew H, Felmingham, Kim, Das, Pritha, Hughes, Gerard, Peduto, Anthony S, Bryant, Richard A, Williams, Leanne M
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 15.08.2007
Elsevier
Subjects
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
Biological and medical sciences
Comorbidity
Depression
Medical sciences
Mood disorders
Post-traumatic stress disorder
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
PTSD
Radiology
PTSD
Comorbidity
Depression
Mood disorder
Human
Affect affectivity
Posttraumatic syndrome
Anxiety disorder
Emotion emotionality
Posttraumatic stress disorder
Nuclear magnetic resonance imaging
Stress
Fear
Concomitant disease
Medical imagery
Functional imaging
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Summary:Abstract Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal–amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity.
ISSN:0925-4927
1872-7506
DOI:10.1016/j.pscychresns.2007.01.010