Lens regeneration: scientific discoveries and clinical possibilities

• Published in: Molecular biology reports Vol. 48; no. 5; pp. 4911 - 4923
• Main Authors: Gu, Yuzhou, Yao, Ke, Fu, Qiuli
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.05.2021; Springer Nature B.V
• Subjects: Animal Anatomy; Animal Biochemistry; Autografts; Biomedical and Life Sciences; Cataracts; Embryo cells; Histology; Life Sciences; Morphology; Pluripotency; Review; Signal transduction; Stem cells; Wnt protein; Regeneration; Cataract; Lens; Stem cells
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-021-06489-5

In the process of exploring new methods for cataract treatment, lens regeneration is an ideal strategy for effectively restoring accommodative vision and avoiding postoperative complications and has great clinical potential. Lens regeneration, which is not a simple repetition of lens development, depends on the complex regulatory network comprising the FGF, BMP/TGF-β, Notch, and Wnt signaling pathways. Current research mainly focuses on in situ and in vitro lens regeneration. On the one hand, the possibility of the autologous stem cell in situ regeneration of functional lenses has been confirmed; on the other hand, both embryonic stem cells and induced pluripotent stem cells have been induced into lentoid bodies in vitro which are similar to the natural lens to a certain extent. This article will briefly summarize the regulatory mechanisms of lens development, describe the recent progress of lens regeneration, explore the key molecular signaling pathways, and, more importantly, discuss the prospects and challenges of their clinical applications to provide reference for clinical transformations. Graphic abstract