Synthesis, antimicrobial activity and anti-biofilm activity of novel tetrazole derivatives

In the development of antimicrobial agents, we designed and synthesized novel tetrazole derivatives. The structures of compounds and were characterized by IR, H NMR, C NMR, MS and elemental analysis. These compounds were tested for their antimicrobial activity against a series of strains , and and f...

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Bibliographic Details
Published inHeterocyclic communications Vol. 23; no. 4; pp. 325 - 330
Main Authors Dofe, Vidya S., Sarkate, Aniket P., Kathwate, Santosh H., Gill, Charansingh H.
Format Journal Article
LanguageEnglish
Published Berlin De Gruyter 28.08.2017
Walter de Gruyter GmbH
Subjects
antibiofilm
Antiinfectives and antibacterials
antimicrobial
Antimicrobial agents
Biofilms
Derivatives
E coli
flavones
Fungicides
Infrared radiation
NMR
Nuclear magnetic resonance
Pseudomonas aeruginosa
Streptomycin
Studies
tetrazole
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Summary:In the development of antimicrobial agents, we designed and synthesized novel tetrazole derivatives. The structures of compounds and were characterized by IR, H NMR, C NMR, MS and elemental analysis. These compounds were tested for their antimicrobial activity against a series of strains , and and for antifungal activity against the strains , and . Compounds , , , and exhibit potent antimicrobial activities compared to the reference drugs streptomycin and miconazole. Tetrazole derivatives also inhibit biofilm formation and compound exhibits best anti-biofilm activity with a biofilm inhibitory concentration (BIC) as low as 0.9 μ
ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2017-0016