C-C, C-O and C-N bond formation via rhodium(III)-catalyzed oxidative C-H activation

Rhodium(III)-catalyzed direct functionalization of C-H bonds under oxidative conditions leading to C-C, C-N, and C-O bond formation is reviewed. Various arene substrates bearing nitrogen and oxygen directing groups are covered in their coupling with unsaturated partners such as alkenes and alkynes....

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Published inChemical Society reviews Vol. 41; no. 9; pp. 3651 - 3678
Main Authors Song, Guoyong, Wang, Fen, Li, Xingwei
Format Journal Article
LanguageEnglish
Published England 01.01.2012
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Summary:Rhodium(III)-catalyzed direct functionalization of C-H bonds under oxidative conditions leading to C-C, C-N, and C-O bond formation is reviewed. Various arene substrates bearing nitrogen and oxygen directing groups are covered in their coupling with unsaturated partners such as alkenes and alkynes. The facile construction of C-E (E = C, N, S, or O) bonds makes Rh(III) catalysis an attractive step-economic approach to value-added molecules from readily available starting materials. Comparisons and contrasts between rhodium(III) and palladium(II)-catalyzed oxidative coupling are made. The remarkable diversity of structures accessible is demonstrated with various recent examples, with a proposed mechanism for each transformation being briefly summarized (critical review, 138 references).
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ISSN:0306-0012
1460-4744
DOI:10.1039/c2cs15281a