Handwritten pattern recognition for early Parkinson’s disease diagnosis

• Published in: Pattern recognition letters Vol. 125; pp. 78 - 84
• Main Authors: Bernardo, Lucas S., Quezada, Angeles, Munoz, Roberto, Maia, Fernanda Martins, Pereira, Clayton R., Wu, Wanqing, de Albuquerque, Victor Hugo C.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2019
• Subjects: image processing; machine learning; Parkinson’s disease; image processing; 41A10; 65D05; 65D17; machine learning; 41A05; Parkinson’s disease
• ISSN: 0167-8655; 1872-7344
• DOI: 10.1016/j.patrec.2019.04.003

•A new software to Parkinson’s diagnosis was developed.•Three machine learning algorithms (SVM, OPF, and Bayesian classifier) were compared.•An experimental evaluation with 20 patients were made. Parkinson’s disease is a neurodegenerative disorder that affects around 10 million people in the world and is slightly more prevalent in males. It is characterized by the loss of neurons in a region of the brain known as substantia nigra. The neurons of this region are responsible for synthesizing the neurotransmitter dopamine, and a decrease in the production of this substance may cause motor symptoms, a characteristic of the disease. To obtain a definitive diagnosis, the patient’s medical history is analyzed and the subject submitted to a series of clinical exams. One of these exams that can take place in the clinical environment comprises asking the patient to create a series of specific drawings. Our work is based on asking the patients to draw using a software developed for this specific purpose. The drawings will then be passed through a series of image methods to reduce noises and extract the characteristics of 11 metrics of each drawing; finally, these 11 metrics will be stored. Machine learning techniques such as Optimum-Path Forest, Support Vector Machine remove, and Naive Bayes use the dataset to search and learn of the characteristics for the process of classifying individuals distributed into two classes: sick and healthy.