Dual functional electrospun nanofiber membrane with ROS scavenging and revascularization ability for diabetic wound healing

• Published in: Colloid and interface science communications Vol. 48; p. 100620
• Main Authors: Sheng, Zheqian, Xu, Yingge, Tong, Zongrui, Mao, Zhengwei, Zheng, Yueliang
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.05.2022
• Subjects: Anti-inflammatory; Diabetic wounds; Electrospun nanofiber membrane; Polydopamine; Vascular regeneration; Diabetic wounds; Polydopamine; Vascular regeneration; Anti-inflammatory; Electrospun nanofiber membrane
• ISSN: 2215-0382; 2215-0382
• DOI: 10.1016/j.colcom.2022.100620

Diabetic wounds afflict numerous patients due to poor healing and risk of amputation, mainly caused by abnormal inflammatory conditions and peripheral vascular disease. Herein, we designed a dual functional electrospun membrane consisting of polycaprolactone/sulfated chitosan nanofibers and polydopamine (PDA) nanoparticles to assist diabetic wound healing. The vascular endothelial growth factor binds with sulfated chitosan and loaded in the nanofibers for revascularization. The reactive oxygen species (ROS) scavenging ability of PDA nanoparticles sprayed on the surface of nanofibers is verified by 1,1-diphenyl-2-trinitrophenylhydrazine method (DPPH method). The in vivo experiments confirmed the dual functional electrospun membrane could alleviate inflammation and promote diabetic wound healing. Such a membrane with anti-inflammatory and pro-angiogenic effects could be a promising candidate for diabetic chronic wound care. [Display omitted] •VEGF and polydopamine nanoparticles are integrated into an electrospun membrane.•PCL/PDA@VEGF has good antioxidant activity.•Sustained release of VEGF was achieved using sulfated chitosan.•PCL/PDA@VEGF promotes diabetic wound repair in vivo.