Bacterial and Archaeal S-Layers as a Subject of Nanobiotechnology

Many bacteria and archaea have a crystalline surface layer (S-layer), which overlies the cell envelope. S-layers each consist of one protein or glycoprotein species. Protein subunits of the S-layer noncovalently interact with each other and with the underlying cell-envelope component. On average, th...

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Bibliographic Details
Published inMolecular biology (New York) Vol. 38; no. 4; pp. 482 - 493
Main Author Debabov, V. G.
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.07.2004
Subjects
Archaea
Bacteria
Bacteriology
Biotechnology
Cellular biology
Molecular biology
Nanotechnology
Proteins
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Summary:Many bacteria and archaea have a crystalline surface layer (S-layer), which overlies the cell envelope. S-layers each consist of one protein or glycoprotein species. Protein subunits of the S-layer noncovalently interact with each other and with the underlying cell-envelope component. On average, the S-layer lattice has pores of 2-6 nm and is 5-10 nm high. Isolated S-layer proteins recrystallize to form two-dimensional crystalline structures in solution, on a solid support, and on planar lipid membranes. Owing to this unique property, S-layers have a broad range of applications. This review focuses on the structural features and applications of S-layers and their proteins, with special emphasis on their use in nanobiotechnology.
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ISSN:0026-8933
1608-3245
DOI:10.1023/B:MBIL.0000036999.77762.6a