Functionalized SBA-15 for controlled release of poorly soluble drug, Erythromycin

• Published in: Microporous and mesoporous materials Vol. 258; pp. 114 - 121
• Main Authors: Pathan, Soyeb, Solanki, Priyanka, Patel, Anjali
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.03.2018
• Subjects: 12-Tungstophosphoric acid; Effect of 12-Tungstophosphoric acid; Erythromycin; Release study; Relese kinetic and mechanism; SBA-15; Effect of 12-Tungstophosphoric acid; Erythromycin; 12-Tungstophosphoric acid; Release study; SBA-15; Relese kinetic and mechanism
• ISSN: 1387-1811; 1873-3093
• DOI: 10.1016/j.micromeso.2017.09.012

SBA-15 was functionalized by 12-tungstophosphoric acid followed by loading of poorly water soluble drug, Erythromycin and Characterized by various physicochemical techniques such as TGA, FT-IR, Nitrogen adsorption-desorption, XRD and TEM. In-vitro controlled release studies of Erythromycin in Simulated Body Fluid were carried out under stirring as well as static conditions. In order to see the influence of inorganic moiety on release rate of drug, study was also carried out with Erythromycin loaded unfunctionalized SBA-15. A study on release mechanism and release kinetics using Higuchi model, Koresmeyer-Peppas model and Extended kinetic model shows that 12-tungstophosphoric acid has significant influence on the release rate of Erythromycin. Erythromycin was loaded to unfunctionalized SBA-15 as well as Heteropoly acid functionalized- SBA-15 and effect of functionalization on control release of drug was studied. [Display omitted] •Functionalization of SBA-15 using 12-tungstophosphoric acid (TPA).•Encapsulation of Erythromycin into SBA-15, TPA-SBA-15 and their characterization.•Comparison of release profile of Erythromycin loaded into SBA-15 and TPA-SBA-15.•Effect of TPA on release rate of Erythromycin.•Investigation of release mechanism and release kinetics.