Synthesis of a cyclic peptide/protein using the NEXT-A reaction followed by cyclization

By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 47; no. 32; pp. 9116 - 9118
Main Authors Hamamoto, Toshimasa, Sisido, Masahiko, Ohtsuki, Takashi, Taki, Masumi
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 28.08.2011
Subjects
Amino Acid Sequence
Chemistry
Chemistry, Multidisciplinary
Cyclization
Cysteine - chemical synthesis
Cysteine - chemistry
Molecular Sequence Data
Peptides, Cyclic - chemical synthesis
Peptides, Cyclic - chemistry
Physical Sciences
Science & Technology
PEPTIDES
N-TERMINUS
PROTEINS
NONNATURAL AMINO-ACIDS
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Summary:By using the NEXT-A reaction, we introduced a non-natural amino acid at the N-terminus of a peptide/protein that contained a cysteine unit. The side chain of the introduced amino acid spontaneously reacted with the cysteine to afford a cyclic peptide/protein.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc12196k