SHOCing RAF into action

Recent structures of the three-way complex formed by the scaffold protein SHOC2, the small G protein M-RAS and protein phosphatase 1 (PP1) provide a tantalizing insight into the activation of RAF, the oncogenic kinase and downstream effector of RAS that drives cell proliferation and survival.

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Bibliographic Details
Published inNature structural & molecular biology Vol. 29; no. 10; pp. 958 - 960
Main Authors Mott, Helen R., Owen, Darerca
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.10.2022
Nature Publishing Group
Subjects
631/535/1258
631/535/1266
631/80/86
692/699/67
Binding sites
Biochemistry
Biological Microscopy
Biomedical and Life Sciences
Cancer
Cell cycle
Cell proliferation
Cell survival
Kinases
Life Sciences
Membrane Biology
Molecular biology
Mutation
News & Views
news-and-views
Phosphoprotein phosphatase
Protein phosphatase
Protein Structure
Proteins
Ras protein
Signal transduction
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Summary:Recent structures of the three-way complex formed by the scaffold protein SHOC2, the small G protein M-RAS and protein phosphatase 1 (PP1) provide a tantalizing insight into the activation of RAF, the oncogenic kinase and downstream effector of RAS that drives cell proliferation and survival.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1545-9993
1545-9985
DOI:10.1038/s41594-022-00843-2