A stereolibrary of conformationally restricted amino acids based on pyrrolidinyl/piperidinyloxazole motifs

A stereolibrary of conformationally restricted oxazole-containing amino acids, namely all isomers of 5–pyrrolydinyl- and 5-piperidinyloxazole-4-carboxylic acids, were designed and synthesized in three steps by the reaction of the corresponding -Boc-protected amino acids and ethyl isocyanoacetate. Th...

Full description

Saved in:
Bibliographic Details
Published inHeterocyclic communications Vol. 21; no. 6; pp. 391 - 395
Main Authors Artamonov, Oleksiy S., Bulda, Taras, Fam, Tkhe Kyong, Slobodyanyuk, Evgeniy Y., Volochnyuk, Dmitry M., Grygorenko, Oleksandr O.
Format Journal Article
LanguageEnglish
Published Berlin De Gruyter 01.12.2015
Walter de Gruyter GmbH
Subjects
Amino acids
conformational restriction
lead-oriented synthesis
Molecular biology
oxazoles
peptidomimetics
Pharmacology
Online AccessGet full text

Cover

More Information
Summary:A stereolibrary of conformationally restricted oxazole-containing amino acids, namely all isomers of 5–pyrrolydinyl- and 5-piperidinyloxazole-4-carboxylic acids, were designed and synthesized in three steps by the reaction of the corresponding -Boc-protected amino acids and ethyl isocyanoacetate. These natural products-inspired amino acids are valuable building blocks for the synthesis of peptidomimetics and potential lead compounds for drug discovery.
ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2015-0137