Synthesis of 2-Amino-octa-4,7-Dien-1-ol (2): Key Intermediate for Mycothiazole Natural Product and Analogs

Starting from L-aminoacids, facile methods for the preparation 2-aminocta-4,7-dien-ol with different stereochemistry have been developed as key intermediates of mycothiazole and analogs.

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Bibliographic Details
Published inSynthetic communications Vol. 35; no. 11; pp. 1481 - 1492
Main Authors Mahler, Graciela, Serra, Gloria, Manta, Eduardo
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 01.06.2005
Taylor & Francis
Subjects
1,2-Aminoalcohols
Chemistry
Chemistry, Organic
L-aminoacids
Physical Sciences
porcine kidney acetylase
Science & Technology
Wittig reaction
1,2-aminoalcohols
Wittig reaction
POLYKETIDE HETEROCYCLE
L-aminoacids
porcine kidney acetylase
THIAZOLINES
DERIVATIVES
DEOXO-FLUOR
OXAZOLINES
ALKALOIDS
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Summary:Starting from L-aminoacids, facile methods for the preparation 2-aminocta-4,7-dien-ol with different stereochemistry have been developed as key intermediates of mycothiazole and analogs.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-200057988