In vitro evaluation of live attenuated vaccines against Salmonella enteritidis: cell-mediated immune response

• Published in: Italian journal of animal science Vol. 6; no. 3; pp. 301 - 304
• Main Authors: Campagnari, Evelyn, Rossi, Giulia, Franciosi, Carlo, Girelli, Damiano, Giovanardi, Davide, Ricci, Antonia, Bianchi, Ezio, Prandini, Francesco, Pesente, Patrizia, Torriani, Sandra
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 2007; Taylor & Francis Group
• Subjects: Salmonella enteritidis, Live vaccine, Cellular-mediated immune response
• ISSN: 1828-051X; 1594-4077; 1828-051X
• DOI: 10.4081/ijas.2007.301

The use of Salmonella enteritidis (SE) live attenuated vaccines is one of the major tool to reduce this infection in commercial poultry. In this work, techniques, evaluating the presence and the expression of some cytokines, were studied to improve the knowledge of the cellular-mediated immune response following SE vaccination. This study demonstrated that SE vaccination enhances the production of INF-γ, IL-8, iNOs, while downregulates IL-1β. Between these immunologic parameters, the evaluation of INF-γ seems to be the most significant and easy test to plan and optimize SE vaccination programs.