Post‐tuberculosis respiratory impairment in Gambian children and adolescents: A cross‐sectional analysis
Background Although post‐tuberculosis lung disease (PTLD) is a known consequence of pulmonary tuberculosis (pTB), few studies have reported the prevalence and spectrum of PTLD in children and adolescents. Methods Children and adolescent (≤19 years) survivors of pTB in the Western Regions of The Gamb...
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Published in | Pediatric pulmonology Vol. 59; no. 7; pp. 1912 - 1921 |
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Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Wiley Subscription Services, Inc
01.07.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Background
Although post‐tuberculosis lung disease (PTLD) is a known consequence of pulmonary tuberculosis (pTB), few studies have reported the prevalence and spectrum of PTLD in children and adolescents.
Methods
Children and adolescent (≤19 years) survivors of pTB in the Western Regions of The Gambia underwent a respiratory symptom screening, chest X‐ray (CXR) and spirometry at TB treatment completion. Variables associated with lung function impairment were identified through logistic regression models.
Results
Between March 2022 and July 2023, 79 participants were recruited. The median age was 15.6 years (IQR: 11.8, 17.9); the majority, 53/79 (67.1%), were treated for bacteriologically confirmed pTB, and 8/79 (10.1%) were children and adolescents living with HIV. At pTB treatment completion, 28/79 (35.4%) reported respiratory symptoms, 37/78 (47.4%) had radiological sequelae, and 45/79 (57.0%) had abnormal spirometry. The most common respiratory sequelae were cough (21/79, 26.6%), fibrosis on CXR (22/78, 28.2%), and restrictive spirometry (41/79, 51.9%). Age at TB diagnosis over ten years, undernutrition and fibrosis on CXR at treatment completion were significantly associated with abnormal spirometry (p = .050, .004, and .038, respectively).
Conclusion
Chronic respiratory symptoms, abnormal CXR, and impaired lung function are common and under‐reported consequences of pTB in children and adolescents. Post‐TB evaluation and monitoring may be necessary to improve patient outcomes. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 8755-6863 1099-0496 1099-0496 |
DOI: | 10.1002/ppul.27009 |