Chiral discrimination in the exchange of α‐tocopherol stereoisomers between plasma and red blood cells

The transport of 2R,4′R, 8′R‐α‐tocopherol and 2S,4′R,8′R‐α‐tocopherol from plasma into rat red blood cell membranes occurs with essentially no chiral discrimination. The previously demonstrated (10) preference of red blood cell membranes favoring 2R,4′R,8′R‐α‐tocopherol over the 2S,4′R, 8′R stereois...

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Bibliographic Details
Published inLipids Vol. 22; no. 7; pp. 469 - 473
Main Authors Cheng, S. C., Burton, G. W., Ingold, K. U., Foster, D. O.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer‐Verlag 01.07.1987
Springer
Subjects
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Deuterium
Erythrocytes - metabolism
Fundamental and applied biological sciences. Psychology
Kinetics
Lipids
Male
Other biological molecules
Rats
Rats, Inbred Strains
Stereoisomerism
Structure-Activity Relationship
Vitamin E - blood
Red blood cell
Metabolism
Tocopherol
Blood
Vitamin
Blood plasma
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Summary:The transport of 2R,4′R, 8′R‐α‐tocopherol and 2S,4′R,8′R‐α‐tocopherol from plasma into rat red blood cell membranes occurs with essentially no chiral discrimination. The previously demonstrated (10) preference of red blood cell membranes favoring 2R,4′R,8′R‐α‐tocopherol over the 2S,4′R, 8′R stereoisomer is shown to be due to better retention of the former compound, i.e., to preferential retention of natural vitamin E.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0024-4201
1558-9307
DOI:10.1007/BF02540361