PHYSICAL DEPENDENCE ON MEPROBAMATE AFTER REPEATED ORAL ADMINISTRATION IN RATS

The physical dependence potential of meprobamate (MPB) was compared with that of phenobarbital (PHB) and codeine (COD) to ascertain whether MPB produces definite physical dependence in the rat. Rats were treated orally with MPB (maintenance dosage=800 mg/kg×2/day), PHB (100×2) or COD (50×2) twice a...

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Bibliographic Details
Published inJapanese journal of pharmacology Vol. 33; no. 6; pp. 1171 - 1176
Main Authors NAKAMURA, Hideo, SHIMIZU, Masanao
Format Journal Article
LanguageEnglish
Published Kyoto Japanese Pharmacological Society 01.12.1983
Subjects
Administration, Oral
Animals
Biological and medical sciences
Body Temperature - drug effects
Body Weight - drug effects
Codeine
Drug toxicity and drugs side effects treatment
Humans
Male
Medical sciences
Meprobamate - pharmacology
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Phenobarbital
Rats
Rats, Inbred Strains
Substance Withdrawal Syndrome
Substance-Related Disorders
Rat
Toxicity
Rodentia
Oral administration
Multiple dose
Vertebrata
Mammalia
Tranquillizer
Animal
Dependence
Withdrawal syndrome
Barbituric
Comparative study
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Summary:The physical dependence potential of meprobamate (MPB) was compared with that of phenobarbital (PHB) and codeine (COD) to ascertain whether MPB produces definite physical dependence in the rat. Rats were treated orally with MPB (maintenance dosage=800 mg/kg×2/day), PHB (100×2) or COD (50×2) twice a day (10:00 a.m. and 5:00 p.m.) for a total of 21 days; the treatment was ceased for 3 days after administration for 7 days, and the last dosing was performed on day 27. During intoxication and after the withdrawal, the MPB treated rats exhibited behaviour and withdrawal signs similar to those seen in the PHB treated rats, but not the COD treated rats. After withdrawal of drugs, definite weight loss was observed in all the rats given drugs, and the recovery of the MPB and PHB treated rats was clearly later than that of the COD treated rats. A long-lasting increase in rectal temperature was observed after the withdrawal in the MPB and PHB treated rats; a decrease was seen in the COD treated rats. From these results, it is concluded that definite physical dependence on MPB, similar to that on PHB but different from that on COD, was developed after repeated oral administration for a total of 21 days in the rat.
ISSN:0021-5198
1347-3506
DOI:10.1016/S0021-5198(19)52417-9