Treatment of Infected Wounds in the Age of Antimicrobial Resistance: Contemporary Alternative Therapeutic Options

As antibiotic resistance increases and antimicrobial options diminish, there is a pressing need to identify and develop new and/or alternative (non-antimicrobial-based) wound therapies. The authors describe the implications of antibiotic resistance on their current wound treatment paradigms and revi...

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Bibliographic Details
Published inPlastic and reconstructive surgery (1963) Vol. 142; no. 4; p. 1082
Main Authors Karinja, Sarah J, Spector, Jason A
Format Journal Article
LanguageEnglish
Published United States 01.10.2018
Subjects
Anti-Bacterial Agents - therapeutic use
Anti-Infective Agents, Local - therapeutic use
Antimicrobial Cationic Peptides - therapeutic use
Bacteriophages
Bandages
Biological Factors - therapeutic use
Drug Resistance, Bacterial
Honey
Humans
Photochemotherapy - methods
Plasma
Reactive Oxygen Species - therapeutic use
Silver - therapeutic use
Wound Healing
Wound Infection - therapy
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Summary:As antibiotic resistance increases and antimicrobial options diminish, there is a pressing need to identify and develop new and/or alternative (non-antimicrobial-based) wound therapies. The authors describe the implications of antibiotic resistance on their current wound treatment paradigms and review the most promising non-antibiotic-based antimicrobial agents currently in research and development, with a focus on preclinical and human studies of therapeutic bacteriophages, antimicrobial peptides, cold plasma treatment, photodynamic therapy, honey, silver, and bioelectric dressings.
ISSN:1529-4242
DOI:10.1097/PRS.0000000000004799