HLA-B16 antigens: sequence of the ST-16 antigen, further definition of two B38 subtypes and evidence for convergent evolution of B3902

• Published in: Tissue antigens Vol. 45; no. 1; p. 18
• Main Authors: Adams, E J, Martinez-Naves, E, Arnett, K L, Little, A M, Tyan, D B, Parham, P
• Format: Journal Article
• Language: English
• Published: England 01.01.1995
• Subjects: Alleles; Amino Acid Sequence; B-Lymphocytes - immunology; Base Sequence; Biological Evolution; Cell Line, Transformed; DNA, Complementary; HLA-B Antigens - chemistry; HLA-B Antigens - genetics; Humans; Mexican Americans; Molecular Sequence Data; Sequence Alignment
• ISSN: 0001-2815
• DOI: 10.1111/j.1399-0039.1995.tb02410.x

The ST-16 antigenic specificity of the HLA-B locus is defined as a B39 variant of Mexican-Americans. Nucleotide sequencing of cDNA shows the ST-16 allele (B*3905) differs from B*39011 by a single substitution that substitutes tyrosine for aspartic acid at position 74 of the mature class I heavy chain. The complete coding region sequence for the common caucasoid allele encoding the B38 antigen has been determined. This B*3801 allele differs from B*3802 at two nucleotide substitutions within the Bw4 sequence motif. B*3801 and B*3802 may have been derived independently from B*39011 by conversion events with B alleles donating distinctive Bw4 motifs. A novel allele B*39022 derived from a Colombian Indian differs from the B*39021 allele of Japanese origin at two widely separated silent substitutions. Comparison of sequences for the known B16 alleles suggest that B*39021 and B*39022 were independently derived by recombination from B*39013 and B*39011 respectively.