Primary pulmonary extraskeletal Ewing sarcoma/Primitive neuroectodermal tumor: Two case reports

• Published in: Egyptian Journal of Bronchology Vol. 11; no. 2; pp. 161 - 164
• Main Authors: Sobh, Eman, El-Sheshtawy, Wael H., Anis, Shady E.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2017; Springer; Springer Nature B.V; SpringerOpen
• Subjects: Cancer; Care and treatment; Case Report; Case reports; Chemotherapy; Ewing sarcoma; Ewing's sarcoma; Ewings sarcoma; extraskeletal Ewing sarcoma; Immunohistochemistry; lung primary; Medicine & Public Health; primitive neuroectodermal tumor; Tumor necrosis factor; Ewing sarcoma; lung primary; extraskeletal Ewing sarcoma; primitive neuroectodermal tumor
• ISSN: 1687-8426; 2314-8551
• DOI: 10.4103/ejb.ejb_48_16

Primary pulmonary extraskeletal Ewing sarcoma (EES)/ primitive neuroectodermal tumor is an extremely rare tumor with only few cases reported in the literature. In this study, we present two cases of primary pulmonary EES diagnosed and treated at our institution. The median age was 20 years (range: 19–21). Cough, dyspnea, and hemoptysis were the predominant features at presentation, associated with a large lung mass on imaging. Image-guided core needle biopsies were the diagnostic modalities for both patients. Initial histopathology showed malignant small round cell tumor, which has been confirmed by immunohistochemistry as EES. Both patients received neoadjuvant chemotherapy followed by surgery; postoperative pathology for the first patient showed 98% tumor necrosis, whereas the second patient’s pathology showed no evidence of residual tumor after complete surgical excision.