Exploring promising minor natural phenolic compounds in neuroprotection‐related preclinical models

Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are characterised by the progressive loss of specific neuronal cell populations due to multifactorial factors, including neurochemical and immunological disturbances. Consequently, patients can develop cogniti...

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Published inBasic & clinical pharmacology & toxicology Vol. 134; no. 6; pp. 770 - 777
Main Authors Moreira Vasconcelos, Carlos Franciney, Neugebauer, Agnieszka Zofia, Basto Souza, Ricardo
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.06.2024
Subjects
Alzheimer Disease - drug therapy
Alzheimer's disease
Animals
Disease Models, Animal
Eugenol
Humans
Immunology
Movement disorders
Neurodegenerative diseases
Neurodegenerative Diseases - drug therapy
Neuroprotection
Neuroprotection - drug effects
Neuroprotective Agents - pharmacology
Parkinson Disease - drug therapy
Parkinson's disease
Phenolic compounds
Phenols
Phenols - pharmacology
polyphenols
Quality of life
Resveratrol
secondary metabolites
polyphenols
secondary metabolites
Eugenol
neuroprotection
Resveratrol
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Summary:Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are characterised by the progressive loss of specific neuronal cell populations due to multifactorial factors, including neurochemical and immunological disturbances. Consequently, patients can develop cognitive, motor and behavioural dysfunctions, which lead to impairments in their quality of life. Over the years, studies have reported on the neuroprotective properties inherent in phenolic compounds. Therefore, this review highlights the most recent scientific findings regarding phenolic compounds as promising neuroprotective molecules against neurodegenerative diseases.
Bibliography:Died February 6, 2024.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1742-7835
1742-7843
DOI:10.1111/bcpt.14006