Safety Considerations in Prescription of NSAIDs for Musculoskeletal Pain: A Narrative Review

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are frequently prescribed for the treatment of painful musculoskeletal conditions. When prescribing oral NSAIDs, clinicians must consider coexisting cardiovascular, cerebrovascular, gastrointestinal, and renal disease because oral NSAIDs are associated w...

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Published inPM & R Vol. 10; no. 12; pp. 1404 - 1411
Main Authors Hatt, Katie M., Vijapura, Anita, Maitin, Ian B., Cruz, Ernesto
Format Journal Article
LanguageEnglish
Published United States 01.12.2018
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Summary:Nonsteroidal anti‐inflammatory drugs (NSAIDs) are frequently prescribed for the treatment of painful musculoskeletal conditions. When prescribing oral NSAIDs, clinicians must consider coexisting cardiovascular, cerebrovascular, gastrointestinal, and renal disease because oral NSAIDs are associated with a broad spectrum of adverse effects on these systems. The different safety profiles of NSAIDs can be attributed to differences in the extent to which the drug inhibits cyclo‐oxygenase‐1 vs ‐2 and their potential for drug‐drug interactions. This narrative review intends to guide the clinician in prescribing oral NSAIDs while taking into consideration these comorbid conditions and drug interactions. Level of Evidence III
Bibliography:Disclosure: nothing to disclose
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ISSN:1934-1482
1934-1563
DOI:10.1016/j.pmrj.2018.06.011